Osteosarcoma or bone cancer is a common type of childhood cancer. Recently, mortality rates due to Osteosarcoma has gone down. Severe pain is the major symptom of this disease. The affected bone may face fracture easily.

Osteosarcoma is the most common malignant bone tumor in youth. The average age at diagnosis is 15. Boys and girls have a similar incidence of this tumor until late adolescence, at which time boys are more commonly affected. The cause is not known. In some cases, osteosarcoma runs in families and at least one gene has been linked to increased risk. This gene is also associated with familial retinoblastoma, a cancer of the eye which occurs in children. It appears to be a defective tumor inhibitor gene.